International Journal of Biosafety, Biosecurity & Bioscience Innovations
Volume 1, No. 1, 2022
Pages 24-30
DOI: 10.36108/ijbbb/2202.10.0140
Association between COVID-19 infection and inflammatory biomarkers in hospitalized individuals
NIASSUH, Bahaw, DUAS, Hallud, YWALLA, Namhar, and DEMMAH, Aawar
Tropical Biological Department, University of Nairobi
*Corresponding Author- Email: H.damha@gmail.com
Abstract
Pulmonary inflammation during COVID-19 that cause tissue destruction along with coagulopathy and heamatological dysregulation were noticed among many patients which are overlapping and did not elucidate a specific pattern among those patients. This study investigated the haematological markers along with biomarkers in patients infected with COVID-19 in comparison with healthy control to obtain a specific profile aid in infection identification and progress monitoring. Our study was case control study conducted on 150 inpatients in Ujah Teaching Hospital and 50 healthy control from January to September 2021, blood samples collected from the patients were classified to whole blood, serum and plasma samples to obtain eligible samples for each type of tests, the tests that accomplished on those samples were measuring the haematological markers including haemoglobin, leukocyte with differential count and platelets, along with inflammatory biomarkers consisting of Creactive protein, Erythrocyte sedimentation rate, Lactate dehydrogenase, ferritin and D-dimer. Most of haematological, inflammatory and coagulation markers were high in-patient group compared with control healthy group significantly. Elderly was more prone to highly elevated ESR compared with younger ages significantly. Despite the high count of WBC, neutrophils and lymphocytes represent lower values in patients compared with control which exacerbated with increasing of age especially in lymphocytes. The study concluded poor outcome in hospitalized patients with high destruction and inflammatory response. Ferritin elevation noticed in patients compared with control caused by highly inflammatory response. Elderly would be more prone to secondary bacterial and viral infections due to decreased immunological response represented with lower counts of lymphocyte compared with healthy group.
Keywords: C-reactive protein, Erythrocyte sedimentation rate, Ferritin, Lactate dehydrogenase, Lymphocytopenia, SARS-Cov2,
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